Blar i Bergen Open Research Archive på forfatter "van der Holt, Bronno"
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The added value of multi-state modelling in a randomized controlled trial: The HOVON 102 study re-analyzed
Bakunina, Katerina; Putter, Hein; Versluis, Jurjen; Koster, Eva A. S.; van der Holt, Bronno; Manz, Markus G.; Breems, Dimitri A.; Gjertsen, Bjørn Tore; Cloos, Jacqueline; Valk, Peter J. M.; Passweg, Jakob; Pabst, Thomas; Ossenkoppele, Gert J.; Löwenberg, Bob; Cornelissen, Jan J.; de Wreede, Liesbeth C. (Journal article; Peer reviewed, 2022)Clofarabine is an active antileukemic drug for subgroups of patients with acute myeloid leukemia (AML). Multi-state models can provide additional insights to supplement the original intention-to-treat analysis of randomized ... -
Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence
Misund, Kristine; Hofste op Bruinink, Davine; Coward, Eivind; Hoogenboezem, Remco M.; Rustad, Even Holth; Sanders, Mathijs A.; Rye, Morten Beck; Sponaas, Anne-Marit; van der Holt, Bronno; Zweegman, Sonja; Hovig, Eivind; Meza, Leonardo Zepeda; Sundan, Anders; Myklebost, Ola; Sonneveld, Pieter; Waage, Anders (Journal article; Peer reviewed, 2022)We investigated genomic and transcriptomic changes in paired tumor samples of 29 in-house multiple myeloma (MM) patients and 28 patients from the MMRF CoMMpass study before and after treatment. A change in clonal composition ...